About Me
My name is Chiara Masnovo. I am a 5th-year Ph.D. candidate in the laboratory of Sergei Mirkin at Tufts University (US). In my research, I study the interactions between the DNA replication fork and long GAA trinucleotide repeats, which form the non-canonical H-DNA structure.
Expansions of GAA repeats in the FXN gene cause the human disease Friedreich's Ataxia and expansions in the FGF14 gene cause SCA27B.
See my CV here.
H-DNA
Contacts
Publications
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Hisey J. A., Radchenko E. A., Mandel N. H., McGinty R. J., Matos-Rodrigues G., Rastokina A., Masnovo C., Ceschi S., Hernandez A., Nussenzweig A., Mirkin S. M. (2024), Pathogenic CANVAS (AAGGG)n repeats stall DNA replication due to the formation of alternative DNA structures. Nucleic Acids Research, gkae124.
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​Masnovo, C., Lobo, A. F., & Mirkin, S. M. (2022). Replication dependent and independent mechanisms of GAA repeat instability. DNA repair, 103385. https://doi.org/10.1016/j.dnarep.2022.103385
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Marsoner, T., Yedavalli, P., Masnovo, C., Fink, S., Schmitzer, K., & Campbell, C. S. (2022). Aurora B activity is promoted by cooperation between discrete localization sites in budding yeast. Molecular Biology of the Cell, mbc-E21. doi/10.1091/mbc.E21-11-0590
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Spivakovsky-Gonzalez, E., Polleys, E. J., Masnovo, C., Cebrian, J., Molina-Vargas, A. M., Freudenreich, C. H., & Mirkin, S. M. (2021). Rad9-mediated checkpoint activation is responsible for elevated expansions of GAA repeats in CST-deficient yeast. Genetics, 219(2), iyab125. https://doi.org/10.1093/genetics/iyab125