Me + MY research
My name is Chiara Masnovo, and I am an American Cancer Society Postdoctoral Research Fellow in the laboratory of Dipanjan Chowdhury at Dana-Farber Cancer Institute/Harvard Medical School.
My research focuses on understanding how cells maintain genome stability and prevent chromosome instability. I am currently investigating DNA damage–independent functions of the DNA repair protein 53BP1.
Prior to joining Dana-Farber, I earned my Ph.D. in Genetics and Molecular Biology from Tufts University, where I studied the mechanisms that allow DNA replication through difficult-to-replicate repetitive DNA sequences in the laboratory of Sergei Mirkin.
You can view my CV here.
Mentoring + Communication
Stay tuned
Publications
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Masnovo, C., Paleiov, Z., Dovrat, D., Baxter, L.K., Movafaghi, S., Aharoni, A. and Mirkin, S.M., 2024. Stabilization of expandable DNA repeats by the replication factor Mcm10 promotes cell viability. Nature Communications, 15(1), p.10532.
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Hisey, J.A., Radchenko, E.A., Mandel, N.H., McGinty, R.J., Matos-Rodrigues, G., Rastokina, A., Masnovo, C., Ceschi, S., Hernandez, A., Nussenzweig, A. and Mirkin, S.M., 2024. Pathogenic CANVAS (AAGGG) n repeats stall DNA replication due to the formation of alternative DNA structures. Nucleic Acids Research, 52(8), pp.4361-4374.
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Hisey J. A., Radchenko E. A., Mandel N. H., McGinty R. J., Matos-Rodrigues G., Rastokina A., Masnovo C., Ceschi S., Hernandez A., Nussenzweig A., Mirkin S. M. (2024), Pathogenic CANVAS (AAGGG)n repeats stall DNA replication due to the formation of alternative DNA structures. Nucleic Acids Research, gkae124.
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Masnovo, C., Lobo, A. F., & Mirkin, S. M. (2022). Replication dependent and independent mechanisms of GAA repeat instability. DNA repair, 103385. https://doi.org/10.1016/j.dnarep.2022.103385
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Marsoner, T., Yedavalli, P., Masnovo, C., Fink, S., Schmitzer, K., & Campbell, C. S. (2022). Aurora B activity is promoted by cooperation between discrete localization sites in budding yeast. Molecular Biology of the Cell, mbc-E21. doi/10.1091/mbc.E21-11-0590
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Spivakovsky-Gonzalez, E., Polleys, E. J., Masnovo, C., Cebrian, J., Molina-Vargas, A. M., Freudenreich, C. H., & Mirkin, S. M. (2021). Rad9-mediated checkpoint activation is responsible for elevated expansions of GAA repeats in CST-deficient yeast. Genetics, 219(2), iyab125. https://doi.org/10.1093/genetics/iyab125